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Paid Clinical Trial Seeking Volunteers with Chronic Plaque Psoriasis to Participate in Clinical Research at Nationwide Locations

If you are a healthy adult, at least 18 years of age, who has been living with moderate-to-severe plaque psoriasis for at least 6 months, you may qualify for a research study enrolling now.   A study to test an investigational drug in patients with chronic plaque psoriasis is currently recruiting patients.  There is no cost for study medication or study-related exams and qualified participants may be compensated for their time and travel. You may be randomized to receive the study medication or placebo.   As with all studies, there are many rules for participation that will be fully reviewed during a screening visit. Reasons you would not qualify for this study; you are a female who is pregnant or breastfeeding, or planning to become pregnant; you are currently using or have recently used a medication for psoriasis that is excluded by this study; you have significant health issues such as TB, Hepatitis B or C, uncontrolled high blood pressure, or HIV.

Locations in Pennsylvania, Maryland, North Carolina, California, & Indiana.   Click The Yellow Box To See Study Information

About This Health Condition: Psoriasis

Psoriasis is a chronic, relapsing disease, with variable clinical features and triggers. It is characterized by thick patches of inflamed, scaly skin, created by abnormal, rapid, and excessive proliferation of skin cells. The cause of the disease is not known, but it is believed to be an autoimmune disease (when the body mistakenly detects its own tissue as foreign and attacks itself).   Psoriasis is estimated to affect 2-2.6% of the U.S population, with a higher incidence in Caucasians; it affects men and women at about the same rate. Children are also affected. Approximately 15% of psoriasis patients may subsequently develop psoriatic arthritis, a potentially debilitating joint condition.

We have learned that psoriasis is not contagious.

  • Genetic research has already identified a few susceptibility genes. Ongoing studies of gene variations associated with the disease’s different clinical features are currently underway.
  • Additional stimuli, such as environmental triggers or expression of still-unidentified genes, are probably required for disease occurrence. Some of these genes are for inflammatory factors that overlap with other autoimmune diseases, such as rheumatoid arthritis, lupus, and type I diabetes.
  • Less toxic, easier-to-use topical treatments are available, including corticosteroids.
  • Phototherapies, using ultraviolet light, are effective for treating moderate-to-severe psoriasis.
  • NIH-supported research has contributed to the development of several biologics—drugs in the form of biological molecules—that are effective in some psoriasis patients. Biologics have fewer side effects than other drugs because they target specific molecules on immune cells, instead of the entire immune system.
  • Trials of biologics that target molecules and cells that regulate the immune system have yielded positive results for psoriasis and psoriatic arthritis. These studies reveal important information about the mechanisms of the diseases, and response to treatment, which will aid the development of future therapies.
  • More attention is given to the psychological impact of the disease; NIH supports research on mental health issues in psoriasis patients. Patients still cope with itching, pain, and social rejection.
  • Cardiovascular disease is increasingly recognized as a common comorbidity with many inflammatory diseases. Preliminary studies suggest that some psoriasis patients may have an increased risk of heart attacks.
  • Many current therapies could be improved by lower cost and ease of use. Small businesses have received NIH funding recently for developing cheaper, easier-to-use topical therapies, as well as less expensive, less time-consuming phototherapies.
  • There are a series of steps, or pathways, in the autoimmune reaction. Many autoimmune diseases appear to share pathways. NIH is funding research to understand the details of these pathways and to interrupt the steps in the autoimmune reaction. Some of these projects, which are focused on treating diabetes, rheumatoid arthritis, lupus, and other diseases, may also help psoriasis patients.
  • The variable clinical features of psoriasis and multi-gene nature of the disease require understanding of the subtypes of the disease and knowledge of the impact of the associated genes on the immune response observed in psoriasis patients. This information will guide the design of new, better, and more personalized therapies.
  • Research advances in the environmental factors that trigger psoriasis and the immune system imbalances that contribute to skin inflammation will lead to new psoriasis therapies.
  • Participation of patients in clinical research is one of the best ways to advance new knowledge and contribute to the development of new treatments.

National Institute of Health

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Strategic Pre-Screening

We deploy pre-screening capabilities that lead to providing pre-qualified subjects to the research site. The IRB approved inclusion and exclusion questions are customized for each study with specific criteria defined by the CRO/Sponsor’s protocol.  Social media marketing and study postings drive interested potential subjects to a simple, encrypted on-line process. Learn more about this service here.

Why Volunteer?

Your participation may help others get a better treatment for their disease and allow researchers to learn more about how diseases can be prevented, identified, or managed.  There are also personalized healthcare attention and financial reward benefits realized by participants.  Learn more on participating in a clinical trial here.

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